Restyl

Restyl


Restyl is the brand name of a medicine called alprazolam. Restyl(R) (Alprazolam) is an anxiloytic, a triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions.
It is highly efficacious for the treatment of Generalized Anxiety Disorder, depression, stress disorders, Traumatic Stress Disorder, Panic Disorder, with or with out Agoraphobia. It also has an analgesic effect on chronic and organic pain of malignant origin.
 It is indicated for short term use for Generalised Anxiety Disorder (GAD). It is not at all safe to use it daily for indefinite duration. Its list of side effects include (which may be experienced by a few patients) Central Nervous System disturbances including impaired alertness, hypotension, GIT upset, amnesia, impaired memory, coordination or attention, dysarthria, ataxia, arthralgia, dyspnoea, increased salivation, paradoxical excitement, withdrawal seizures, tremors, decreased libido and sexual dysfunction. The drug is addictive and causes dependence.



Availability

Alprazolam instant release (IR) is available in 0.125 mg, 0.25 mg, 0.5 mg, 1 mg and 2 mg strength regular and orally disintegrating tablets.[105] Alprazolam Extended Release (XR) is available in 0.5 mg, 1 mg, 2 mg, and 3 mg strength oral.

Alprazolam is available in English-speaking countries under the following brand names:
  
    Alganax
    Alzolam
    Alprax
    Alprose
    Alprox
    Alzam
    Anxirid
    Apo-Alpraz
    Calmax
    Gerax
    Helex
    Kalma
    Ksalol
    Mylan
    Nervin
    Niravam
    Novo-Alprazol
    Nu-Alpraz
    Onax
    Restyl
    Tafil
    Texidep
    Trika
    Tranax
    Xanax
    Xanor
    Zamhexal
    Zolam
    Zopax
    Zotran

 Legal status

In the United States, alprazolam is a prescription drug and is assigned to Schedule IV of the Controlled Substances Act by the Drug Enforcement Administration.[107] Under the UK drug misuse classification system benzodiazepines are class C drugs (Schedule 4).[108] In the UK, alprazolam is not available on the NHS and can only be obtained on private prescription.[109] Internationally, alprazolam is included under the United Nations Convention on Psychotropic Substances as Schedule IV.[110] In Ireland, alprazolam is a Schedule 4 medicine.[111] In Sweden, alprazolam is a prescription drug in List IV (Schedule 4) under the Narcotics Drugs Act (1968).[112] In the Netherlands, alprazolam is a List 2 substance of the Opium Law and is available for prescription


Why do we need to take Restyl(Alprazolam)?

Restyl is very effective in the treatment of Generalized Anxiety in particular. In our day-to-day stress filled lives anxiety seems to be our constant companion. In order to raise the quality of life and relieve us from stress Restyl is a good medication to start with under medical supervision. Restyl also helps patients with panic disorders, depression and so on to lead a comparatively normal and anxiety free life. As we are all aware anxiety can lead to many serious complications especially cardiac problems.

How Does Restyl act?

Their exact mechanism of action is unknown. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis. Alprazolam binds to the GABAA, subtype of the GABA receptor, increasing inhibitory effects of GABA within the central nervous system. The binding site for benzodiazepines is distinct from the binding site for GABA on the GABA receptor.
There are certain things, which you should know before taking Restyl (Alprazolam.)
    Alprazolam concentrations may be reduced by up to 50% in smokers compared to non-smokers
    If Alprazolam is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus and ideally discontinue the drug.
    Alcohol should not be generally consumed during the treatment with Alprazolam
    Alprazolam undergoes transplacental passage and is excreted in human milk, nursing mothers should follow physician’s assistance in this case
Drugs that you need to be careful while taking Restyl
    Avoid Potent CYP3A inhibitors –Increases the drug concentration of Alprazolam for e.g Ketoconazole, Itraconazol, other Azole-type antifungal agents, Nefazodone, Fluvoxamine, Cimetidine, Fluoxetine, Propoxyphene, Oral Contraceptives – In this case dose needs to be reduced to avoid adverse effects
    Potent CYP3A inducers—Carbamazepine may decrease Alprazolam -- in this case dose should be increased in order to achieve desired therapeutic effect
    Possible drug interactions have been reported with Diltiazem, Isoniazid, Macrolide antibiotics such as Erythromycin and Clarithromycin, and Grapefruit juice

Common problems that you may encounter with treatment of Restyl

    Drug withdrawal syndrome is the most common of all
    Psychological Dependence
    Inter Dose Anxiety

Common side effects that may be encountered with the treatment of Restyl

    Sedation
    Somnolence
    Dysarthria
    Abnormal coordination

In geriatric patients the

    dose needs to be properly adjusted and administered as metabolic activities are low in geriatric patients and they suffer from co morbid conditions

In patients with concomitant diseases

    Care should be taken in patients with advanced liver disease
    Also in patients with debilitating disease
    And in patients with impaired renal functions

Important

    Never take Restyl without prescription
    Physician’s assistance is a must when you want to discontinue the drug (cases of seizures have been reported)
    Take care, not to end up as a drug abuser
    Never escalate or reduce the dosage on your own